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Symbol Name ID |
Myd88
myeloid differentiation primary response gene 88 MGI:108005 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Monoclonal immunoglobulin M proteinemia |
Polyclonal elevation of IgM |
Impaired lymphocyte transformation with phytohemagglutinin |
Abnormality of neutrophils |
Leukemia |
Lymphadenopathy |
Splenomegaly |
Subacute progressive viral hepatitis |
Cryoglobulinemia |
Recurrent infections |
| Disease(s) Associated with MYD88 | ||||||||||
| hepatocellular carcinoma | ||||||||||
| lymphoplasmacytic lymphoma |
| Mouse Phenotypes | immune system phenotype |
abnormal dendritic cell differentiation |
decreased B cell proliferation |
increased B cell proliferation |
increased susceptibility to induced colitis |
enlarged spleen |
abnormal somatic hypermutation frequency |
abnormal T-helper 1 cell differentiation |
decreased neutrophil cell number |
increased dendritic cell number |
increased germinal center B cell number |
increased plasma cell number |
decreased effector memory CD4-positive, alpha-beta T cell number |
decreased macrophage cell number |
decreased monocyte cell number |
decreased leukocyte cell number |
abnormal splenic cell ratio |
abnormal neutrophil physiology |
increased IgA level |
increased IgE level |
decreased IgG1 level |
increased IgG1 level |
decreased IgG2b level |
decreased IgG2c level |
decreased IgG3 level |
decreased IgG level |
increased IgM level |
abnormal NK cell physiology |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 17 cell physiology |
abnormal NK T cell physiology |
abnormal memory T cell physiology |
abnormal macrophage physiology |
abnormal microglial cell physiology |
abnormal circulating chemokine level |
decreased circulating interleukin-10 level |
decreased circulating interleukin-12b level |
decreased circulating interleukin-6 level |
decreased circulating tumor necrosis factor level |
increased circulating tumor necrosis factor level |
abnormal cytokine level |
abnormal chemokine level |
decreased CXCL10 level |
abnormal interferon level |
abnormal tumor necrosis factor level |
abnormal immune system physiology |
abnormal adaptive immunity |
abnormal dendritic cell physiology |
abnormal dendritic cell antigen presentation |
abnormal cell-mediated immunity |
abnormal cytokine secretion |
abnormal chemokine secretion |
decreased interferon-alpha secretion |
decreased interferon-gamma secretion |
decreased interleukin-1 beta secretion |
decreased interleukin-10 secretion |
decreased interleukin-12 secretion |
decreased interleukin-12b secretion |
decreased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
decreased susceptibility to induced arthritis |
decreased inflammatory response |
bronchiolitis |
abnormal innate immunity |
abnormal response to infection |
abnormal susceptibility to bacterial infection |
increased susceptibility to bacterial infection |
increased susceptibility to Coronaviridae infection induced morbidity/mortality |
decreased susceptibility to parasitic infection |
increased susceptibility to Herpesvirales infection |
increased susceptibility to Coronaviridae infection |
increased susceptibility to Picornaviridae infection |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88lkd/Myd88lkd | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88m3Btlr/Myd88m3Btlr | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88M4Btlr/Myd88M4Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88poc/Myd88poc | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88tm1.1Defr/Myd88tm1.1Defr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88tm1Aki/Myd88tm1Aki | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88tm1Hlz/Myd88tm1Hlz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88M4Btlr/Myd88+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88poc/Myd88+ | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Myd88em1.1Rsky/Myd88em1.1Rsky (conditional) |
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| Myd88tm1.1Medz/Myd88tm1.1Medz Tg(Cd4-cre)1Cwi/0 (conditional) |
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| Myd88tm1.1Medz/Myd88tm1.1Medz Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Myd88tm1Defr/Myd88tm1Defr Tg(Itgax-cre)1-1Reiz/0 (conditional) |
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| Myd88tm1Defr/Myd88tm1Defr Commd10Tg(Vav1-icre)A2Kio/Commd10+ (conditional) |
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| Myd88tm1Hlz/Myd88tm1Hlz Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Myd88em1.1Rsky/Myd88+ (conditional) |
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| Cd19tm1(cre/ERT2)Rsky/Cd19+ Myd88em1.1Rsky/Myd88+ (conditional) |
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| Ighg1tm1(cre)Cgn/Ighg1+ Myd88em1.1Rsky/Myd88+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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